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NOA-03 Trial of High-Dose Methotrexate in Primary Central Nervous System Lymphoma:Final Report Ann Neurol 57:843-847, Herrlinger,W.,et al, 2005 See this aricle in Pubmed Article Abstract High-dose methotrexate with deferred radiotherapy had only moderate efficacy and was associated with significant neurotoxicity in long-term surviving patients.

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